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Two major Covid-19 studies are withdrawn after the scientists sounded the alarm.
Two studies on Covid-19 were withdrawn Thursday by the scientific journals in which they had appeared.
The studies, published in The Lancet and the New England Journal of Medicine in May, had produced surprising results and changed the course of research on the pandemic.
The Lancet newspaper reported dismal results on the use of chloroquine and hydroxychloroquine to treat Covid-19 patients. This has led to the suspension of certain clinical trials of drugs, notably by the World Health Organization. (Some have since resumed.)
President Trump has repeatedly promoted hydroxychloroquine despite the lack of evidence of its effectiveness against the virus. Its approval had the effect of politicizing the scientific questions that would normally have been left to passionate researchers.
The Lancet, which was allegedly based on data from a huge private patient registry from hundreds of hospitals around the world, concluded that antimalarial drugs were dramatically associated higher rates of cardiac arrhythmias and death in Covid-19 patients. The database was owned by a company called Surgisphere, which is owned by Dr. Sapan Desai, one of the four co-authors.
The other three co-authors, including Dr. Mandeep R. Mehra, a professor at Harvard Medical School, retracted the article Thursday after their attempts to verify the veracity and authenticity of the database were thwarted by the Dr Desai.
Later on Thursday, the New England Journal of Medicine retracted a heart study published in May by the same authors, using data from the same registry. This study would have analyzed 8,910 Covid-19 patients hospitalized until mid-March in 169 medical centers in Asia, Europe and North America. The authors concluded that cardiovascular disease increased their risk of dying.
“Because not all authors were granted access to the raw data and the raw data could not be made available to a third-party auditor, we are unable to validate the main sources of data underlying our article, “wrote the authors. in the study retraction.
For months, a lingering mystery of the coronavirus was the reason why some countries with shaky healthcare systems and overcrowded shantytowns had managed to avoid the brunt of an epidemic hitting Europe and the United States.
As the death toll from the global pandemic approaches 400,000, known cases of viruses are increasing faster than ever – at a rate of more than 100,000 per day. The increase is concentrated in the densely populated low- and middle-income countries of the Middle East, Latin America, Africa and South Asia.
The new direction of the pandemic is bad news for strong men and populists in some of these countries who once garnered political points by touting low infection rates as proof of their leadership virtues.
Russian President Vladimir V. Putin, for example, whose delivery of a medical aid load to the United States in March was seen as an arrogant snub, is grappling with the third largest epidemic in the world, with 440 000 cases that enraged the public. and depressed his approval ratings.
In Egypt, where the rate of new confirmed infections doubled last week, the pandemic has created friction between President Abdel Fattah el-Sissi and doctors who rebelled for lack of protective equipment and training.
And in Brazil, the total death toll exceeded 32,000 on Thursday, with 1,349 deaths in a single day, striking another blow to populist president Jair Bolsonaro, who continued to play down the threat.
“We are sorry for all the dead, but it is everyone’s fate,” he said on Tuesday.
In other developments:
South Korea reported 39 new cases on Friday. Most were in and around Seoul, where a recent wave of infections has been attributed to nightclubs and an e-commerce warehouse.
Thousands of people Hong Kong On Thursday, they flouted the rules of social distancing as they gathered to commemorate the Tiananmen Square massacre.
the European Central Bank has announced that it will increase its bond purchases by an additional 600 billion euros, for a total of 1.35 trillion euros.
Germany announced a package of tax cuts and other measures totaling 130 billion euros.
IsraelThe Knesset Parliament was suspended after a lawmaker said he had tested positive for the virus.
The Trump administration released Thursday New Requirements for States to Report Coronavirus Data Based on Race, Ethnicity, Age and Sex of People Tested for the Virus, to Meet Lawmakers’ Requests for a Better Picture of the Pandemic .
All laboratories will be required to send demographic data to state or local public health services based on the individual’s residence, according to details published by the Department of Health and Social Services.
Dr. Robert R. Redfield, Director of the Centers for Disease Control and Prevention, was faced with a barrage of questions from House legislators on Thursday during a health subcommittee hearing of the often-interrupted response. of his agency for the pandemic, and what some members of Congress have said was his inability to anticipate the effect of the pandemic on black and Hispanic communities.
“We didn’t have the data we needed to answer this question reactively,” said Dr. Redfield.
Public health experts have criticized the Trump administration for failing to address the disproportionate effects of the virus on communities of color. The interrogation took place as large protests continued across the United States against the murder of George Floyd, a black man who died last week in police custody after a white officer knelt on his neck for nearly nine minutes.
Here’s what happened in the United States on Thursday:
Sonia Sotomayor Supreme Court Justice temporarily suspended trial judge orders requiring the Trump administration to transfer more than 800 elderly or medically vulnerable detainees to an Ohio prison where nine prisoners died of the virus. Friday, a court of appeal must hear the arguments in this case.
New York Mayor Bill de Blasio said the city could begin a second phase of reopening “as early as July”, during which offices, stores and personal service businesses like hair salons may reopen with restrictions.
The head of the U.S. Centers for Disease Control and Prevention, Dr. Robert Redfield, told parliamentarians that the federal government and state health departments must dramatically increase the number of tracers working to identify who people are infected with. the coronavirus had come into contact with. He said up to 100,000 would be needed by September.
A US Federal Court of Appeal has sided with Texas Republicans in their legal battle to restrict postal voting during the pandemic, reversing a lower court decision that would have allowed fearful voters to contract the virus to vote by mail rather than in person.
Patients who flooded the Detroit Medical Center emergency room in March and April had symptoms indicative of coronavirus: high fevers and lungs riddled with infection that left them breathless.
With few treatment options, doctors have turned to a familiar intervention: broad-spectrum antibiotics, injectable drugs often used against bacterial infections that cannot be immediately identified. They knew that antibiotics were not effective against viruses, but they feared that patients were vulnerable to life-threatening secondary bacterial infections.
“During the peak wave, our use of antibiotics was wrong,” said Dr. Teena Chopra, director of epidemiology and antibiotic management at the hospital. She and other doctors across the United States who generously dispensed antibiotics during the first weeks of the pandemic said they quickly realized their mistake.
Now the country’s doctors are trying to draw lessons from their overuse of antibiotics, a practice that can boost resistance to life-saving drugs because bacteria mutate and thwart drugs. Antimicrobial resistance is a growing threat that kills 700,000 people every year – a global health crisis that goes on behind the scenes while the coronavirus takes center stage.
In recent weeks, public health experts have been Warning that the same government inaction that helped promote the rapid spread of the coronavirus could trigger an even more deadly epidemic of drug-resistant infections. The UN warns that such an epidemic could kill 10 million people by 2050 if no serious action is taken.
The pipeline of new antimicrobial drugs has become dangerously dry. In the past year, three developers of American antibiotics with promising drugs have ceased operations and most of the global pharmaceutical giants have abandoned the field.
Congressional legislation to tackle the failed antibiotic market has failed to gain ground in recent years, but public health experts hope the coronavirus pandemic can help break the political deadlock in Washington.
Grace Cogan, who is deaf and lives in Jamesville, New York, experiences feelings of anxiety while shopping because masks prevent her from communicating effectively, leaving her to trust the eyes and tilting the eyebrows to understand others. So her boyfriend now does most of the shopping.
“This pandemic has really further divided the inclusion of the hearing and hearing impaired community, or in other words, further isolated us,” she said.
Sign language interpreters are among a growing group of essential workers, often called upon to stand alongside public servants who communicate vital information on television and the Internet. But they are not everywhere.
Roberta J. Cordano, President of Gallaudet University, a liberal arts university for the deaf in Washington, said: “The standard” two adults, six feet apart “has its own inherent bias, assuming that all these social distances are the same: that they hear, see and need no support. ”
Ashlea Hayes, deaf and blind and working as secretary to National Defenders of the Black Deaflives in Compton, California, where she does most of her shopping herself. But lately, she has become more dependent on delivery services and, unable to visit and touch her friends and colleagues, has said that her anxiety has increased.
“The feeling of panic everywhere is overwhelming.” Said Mrs. Hayes.
British pharmaceutical company AstraZeneca said Thursday it had reached an agreement with a vaccine manufacturing giant, the Serum Institute of India, to produce one billion doses of a potential antivirus vaccine for distribution in low- and middle-income countries.
The potential vaccine, designed in an Oxford laboratory, is one of many candidates currently in the clinical trial and has not been proven to work. But governments and non-profit foundations risk hundreds of millions of dollars to organize the production of large volumes of several potential vaccines, including AstraZeneca, so that all of those approved can be quickly distributed.
If its vaccine proves effective, AstraZeneca would now have the capacity to manufacture up to two billion doses by next year, the company said. If ongoing trials are successful, the vaccine could be approved for emergency use in the United States and elsewhere as early as this fall.
AstraZeneca said two nonprofits have agreed to pay $ 750 million for the manufacture and purchase of 300 million doses by the end of this year. These are the Coalition for Epidemic Preparedness Innovation, a relatively recent public-private partnership based in Norway, and the former Gavi vaccine alliance based in Geneva. Both receive funding from several Western governments as well as the Bill & Melinda Gates Foundation.
The U.S. government has agreed to pay for the production of 300 million doses, and Britain has agreed to pay up to 100 million doses.
AstraZeneca CEO Pascal Soriot said during a video conference that during the pandemic, the company would distribute the “not-for-profit” vaccine and allow governments and donors to check its finances to make sure it did not benefit from the vaccine.
“We don’t usually do this,” he added. “It’s a very unique process.”
New York Mayor Bill de Blasio said Thursday the city could begin a second phase of reopening “as early as July”, during which offices, stores and personal service businesses such as salons hairstyle could reopen with restrictions, and restaurants could offer outdoor dining.
The city has not yet started to reopen, but the mayor reiterated that the city was on track to start the first phase on Monday. According to state guidelines, phase 1 regions that continue to meet health-related benchmarks can enter phase 2 after two weeks.
After seven days of overcrowded and above all peaceful protests against racism and police violence in New York, the governor declared that state test criteria were expanded to include anyone who participated in the protests and encouraged people to get tested. The city announced universal tests earlier this week.
Governor Andrew M. Cuomo also said that protesters should inform others that they attended a demonstration and behave as if they had been exposed. Statewide, there have been 52 additional virus-related deaths, he said. Nine counties ringing in the city are slated to enter phase 2 next week, he said, and the state is authorizing drive-in and drive-through degrees.
As more and more Americans return to their offices and stores after months spent indoors, new clusters of coronaviruses continue to emerge. Here is an overview of the rest of the country.
In Las Vegas several casinos reopened on Thursday, with the Bellagio reactivate its fountain and many welcoming players return with social distancing and temperature control measures in place.
In northeast of Mississippi, a recent funeral has spread the virus to at least nine people, some of whom came from other states. In Arkansas, at least 35 people in a boot factory fell ill. And in Kansas City, Mo., health officials announced this week a cluster of more than 200 employees at a facility that makes paper plates and cups.
Most of the larger case groups remain nursing homes, prisons and food processing facilities, all the places where social distancing is difficult. But as the country reopens, and the capacity for testing and searching for contacts develops, epidemics appear in new contexts.
At least 26 workers on a construction site Augusta, Maine, tested positive, with at least 24 people in a Walmart distribution center in Colorado and at least 16 in a convenience store Kansas.
In New Jersey, breweries and wineries can resume offering outdoor tastings on June 15, when restaurants and bars had already been allowed to reopen for outdoor dining, the governor said.
The N.B.A. the owners approve a plan to relaunch the season in July, a key step.
N.B.A. The owners overwhelmingly approved the league’s plan to restart the season with 22 teams at Walt Disney World in Florida in July, according to a person familiar with the results of the vote.
The single site proposal was ratified by a vote of 29 votes to one, with the Portland Trail Blazers as the only opposition, according to the person, who was not allowed to publicly discuss the results. According to the rules of the league, 23 votes for the 30 teams were necessary to pass the measure proposed by the N.B.A. the commissioner, Adam Silver.
The N.B.A. would be among the largest and most watched North American sports leagues to return, following the announcement of the resumption of the National Hockey League, Major Soccer League and National Women’s Soccer League this summer. Voting results first reported by The Athletic.
The NBA return-to-play plan, approved on what would have been the first day of this season’s finals, will then be reviewed by the National Basketball Players Association, which has scheduled a virtual meeting with its members on Friday afternoon, according to three people familiar with the calendar who spoke on condition of anonymity because they were not authorized to discuss it publicly.
It was not immediately clear whether players would be invited to officially vote on the proposal, but the league hopes that the close working relationship that union president Chris Paul of Oklahoma City has with Silver is indicative of the possible approval of the players.
Hundreds of people arrested in New York since police murder of George Floyd last week were detained in cramped cells for more than 24 hours before seeing a judge, sometimes maskless, with health risks in the midst of Defense lawyers told me.
The Legal Aid Society has accused in a trial this week that the prolonged detention of the accused – some arrested while looting, others when they run into police in largely peaceful protests against racism and police brutality – violated state law and their constitutional rights.
Clarence Johnson, 24-year-old Harlem chief arrested on illegal muster charges during a protest in Manhattan on Monday, said he was detained in a cell with about 30 people spaced just two feet apart from clogged toilets. , no soap and no working sink.
Some detainees were coughing and others appeared sick, he said. Johnson said his brother, who was arrested with him, still had not seen a judge on Wednesday night.
Law enforcement officials say they try to treat people quickly, but face logistical hurdles due to the virus being stopped and the number of arrests.
But public defenders claim that the police obstructed the system by referring people to the courts who should have received summons for minor crimes during the protests.
Justice James M. Burke of the Manhattan State Supreme Court on Thursday rejected a legal aid request that the city should release people detained for more than a day, noting that the police department was facing widespread civil unrest during a pandemic. “It’s a crisis in a crisis,” said Justice Burke. “All writs are refused.”
Mr. Floyd himself had the virus in early April, almost two months before his death, according to an official autopsy published in Minnesota on Wednesday. There is no evidence that the virus played a role in his death and the Hennepin County medical examiner said that Mr. Floyd was probably asymptomatic at the time of his death.
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